(Triff et al., 2017)
Triff et al have documented for the first time the chromatin structure associated with gene expression profiles in an in vivo murine colonic tumorigenesis model. Their high-throughput sequencing approach revealed many expected changes at various regulatory stages of gene expression, plus unexpected insight into gene regulation during colon cancer progression. Specifically, they were able to show that AOM (Azoxymethane, a carcinogen) induced transcriptional deregulation was primarily associated with interferon-associated immune response genes, while K4me3 deregulation was linked to genes associated with colon tumorigenesis, perhaps acting as a harbinger of changes in gene activity.
(Triff et al., 2017)
Image By Mariana LadyofHats (edited with adobe ilustrator) [Public domain], via Wikimedia Commons.