The TIGSS High Performance Compute Cluster (HPCC) is tailored for bioinformatics and computational Biology applications, sequence assembly, alignment and analysis and many more. A total of 296 compute cores (592 with HT enabled) with a forty-core high performance/high memory “fat” node plus sixteen blades with sixteen cores each are available on the TIGSS-HPC Cluster. The fat node (edius) has a total of 1 TB of memory and the standard compute nodes have 64 GB each for a total of 2 TB compute memory. The cluster has 70 TB useable high-performance/high-availability network attached storage (NAS). A local WIKI is available describing the general usage guidelines and various software that is available globally on the cluster.