Hsueh Chung Lu et al (Dr. Jianrong Li’s lab) show that STAT3 is activated in myeloid cells near active MS lesions and also show that conditional deletion of Stat3 in myeloid cells abolished symptoms of experimental autoimmune encephalomyelitis (EAE) by suppressing the generation of pathogenic T cells. Functional and transcriptomic analyses of myeloid cells from wild-type and conditional knockout mice implicated antigen processing/presentation and inflammatory cytokine production as the mechanism underlying the effects of STAT3 deletion on impaired T cell activation.


Read More: https://doi.org/10.1073/pnas.1913997117